Background: High-quality development and enhancement of global reputation are important for Chinese biomedical journals. This study analyzed the high-quality development status and strategies of China Oncology since the establishment of the Fifth Editorial Board, aiming to provide a reference for the high-quality development of biomedical journals in China. Methods: This study summarized all strategies adopted from 2020 to 2024 to enhance the competitiveness of China Oncology, including expanding the editorial board members, establishing policies, improving writing quality (following the Enhancing the QUAlity and Transparency Of health Research [EQUATOR] Network guidelines), performing the Principles of Transparency and Best Practice in Scholarly Publishing, and applying for inclusion in international databases. In addition, GraphPad Prism 10.0 was used for graphical analysis. Results: China Oncology enhanced global influence and contributed to the improvement of cancer prevention and treatment. China Oncology has strengthened various capacity building through multidimensional development and has achieved significant results in all aspects, including expanding the editorial board members and establishing a youth editorial board, strictly controlling the academic quality of journals, promoting journal transparency, carrying out an open-access (OA) publishing model with Creative Commons (CC) license CC BY-NC-ND 4.0, expanding inclusion in international databases (indexed by Scopus, Directory of Open Access Journals [DOAJ], Excerpta Medica Database [Embase], EBSCO, Japan Science and Technology [JST], and Index Copernicus), and enhancing content quality by following the EQUATOR Network guidelines. Conclusion: By applying for inclusion in renowned international databases, enhancing academic influence and international visibility by expanding the members of the editorial board, strictly following the EQUATOR Network guidelines and Principles of Transparency and Best Practice in Scholarly Publishing, strengthening publishing ethics, focusing on oncology hotspot studies, and improving the scientific and editorial quality of the manuscripts, Chinese medical journals can achieve high-quality development.

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