Colorectal cancer (CRC) is a leading cause of cancer morbidity and mortality worldwide, with genetic factors playing a significant role in its pathogenesis. This study investigated the prevalence of two single-nucleotide polymorphisms (SNPs) – rs9929218 in the Cadherin 1 (CDH1) gene and rs6983267 in the 8q24 region – among Kurdish CRC patients in Sulaymaniyah, Iraq, and assessed their association with clinicopathological features. Blood samples from 290 CRC patients and 100 healthy controls were analyzed using allele-specific polymerase chain reaction. The frequency of rs9929218 was 20.34% in CRC patients compared to 7% in controls, while rs6983267 was detected in 26.55% of CRC cases versus 11% of controls. Both SNPs were significantly associated with CRC risk in univariate analyses; however, after adjusting for age, sex, tumor grade, and TNM stage in multivariate logistic regression, neither SNP remained an independent risk factor. Nonetheless, both SNPs showed significant associations with advanced tumor stage, nodal involvement, and perineural invasion, suggesting a potential role in disease progression rather than initiation. These findings enhance the understanding of CRC genetics in the Kurdish population and highlight the need for larger, functionally validated studies to confirm these associations.

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