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Research Article

Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment

Xin Li
1,2
Fei Xie
3
Chao Deng
3
Dan Yang
1
Hongle Li
4
Yuanzhi Lu
5
Zhenbin Mao
6
Qingwei Meng
7
Lidong Wang
8
Zhe Wang
9
Jinliang Xing
10
Chong Bai
11
Zhimin Bian
12
Paolo Boffano
13
Steven Brower
14
Rui Chen
15
Wantao Chen
16
Jinhai Deng
17
Xinpei Deng
18
Chunming Ding
19
Jianchun Duan
20
Song Duan
21
Nejat Duzgunes
22
Pierfrancesco Franco
23
Guobin Fu
24
Longmei Guo
25
Ye Guo
26
Ruiqin Han
27
Ling Hao
28
Lang He
29
Yayi He
30
Xiaotong Hu
31
Junmei Jia
32
Yanfang Jiang
33
Weilin Jin
34
Kalevi Kairemo
35
Mohamed Kamal
36,37
Evan T. Keller
38
Rensheng Lai
1
Chao Li
39
Jun Li
40
Lifeng Li
41
Qingxia Li
42
Wenbin Li
43
Xuening Li
44
Yang Li
45
Yongsheng Li
46
Yu Li
47
Mikael S. Lindström
48
Xiaodong Liu
49
Yan Liu
50
Yanqing Liu
51
Zengjun Liu
52
Jose Manuel Lopes
53
Hongyang Lu
54
Xiangwen Luo
1,2
Wenping Ma
55
Hongxue Meng
56
Anjie Min
57
Amancio Carnero Moya
58
Athanasios G. Papavassiliou
59
Xi Pan
60
Min Peng
61
Helmut H. Popper
62
Lixin Qiu
63
Di Qu
64
Axel H. Schönthal
65
Vishal Shelat
66
Yi Shi
67
Alexander Shtil
68
Hifzur R Siddique
69
Yang Song
70
Haichuan Su
70
Min Tang
71
Mengyuan Wang
3
Qiming Wang
72
Shubin Wang
73
Bing Wei
74
Dawei Wu
75
Longxiang Wu
76
Liangbi Xu
77
Yubo Yan
78
Nong Yang
79
Zihuan Yang
80
Zongbi Yi
81
Songtao Yu
82
Heng Zhang
83
Hongmei Zhang
84
Lijuan Zhang
85
Jianfu Zhao
86
Zheng Zhao
87
Shaoquan Zheng
88
Chengzhi Zhou
89
Pu Zhou
90
Qin Zhou
91
Guodong Zhu
92
Qin Yan
93
Minghui Zhang
1,2*
Mingzhu Yin
1,2*

1 Clinical Research Center, Medical Pathology Center, Cancer Early Detection and Treatment Center and Translational Medicine Research Center, Chongqing University Three Gorges Hospital, Chongqing University, Wanzhou, Chongqing

2 School of Medicine Chongqing University, Chongqing University, Shapingba, Chongqing

3 Department of Breast Surgery, Chongqing University Three Gorges Hospital, Chongqing University, Wanzhou, Chongqing

4 The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan

5 Department of Clinical Pathology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong

6 The China Food and Drug Corporation Quality and Safety Promotion Association

7 Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

8 State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan

9 Department of Thyroid, Breast, and Vascular Surgery, Xijing Hospital, The Air Force Medical University, Xi’an, Shaanxi

10 State Key Laboratory of Cancer Biology and Department of Physiology and Pathophysiology, Air Force Medical University, Xi’an, Shaanxi

11 Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, the First Affiliated Hospital of Second Military Medical University, Shanghai

12 Department of Comprehensive, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

13 Division of Dentistry, Vercelli Hospital, Vercelli, Piemonte

14 The Lefcourt Family Cancer Treatment and Wellness Center, Englewood Health, Englewood, New Jersey; Icahn School of Medicine at Mount Sinai, New York City, New York; Hackensack Meridian School of Medicine, Nutley, New Jersey

15 Department of Pathology, Chongqing University Cancer Hospital, Shapingba, Chongqing

16 Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai

17 Richard Dimbleby Laboratory of Cancer Research, School of Cancer & Pharmaceutical Sciences, King’s College London, London, Greater London

18 Sun Yat-sen University Cancer Center, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong

19 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai

20 State Key Laboratory of Molecular Oncology, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

21 Department of Pathology, Chongqing University Three Gorges Hospital, Wanzhou, Chongqing

22 Department of Biomedical Sciences, Arthur A Dugoni School of Dentistry, University of the Pacific, San Francisco, California

23 Department of Translational Medicine (DIMET), University of Eastern Piedmont, Department of Radiation Oncology, ‘Maggiore della Carità’ University Hospital, Novara, Piedmont

24 The Second Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, Shandong; Department of Oncology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong; The Third Affiliated Hospital of Shandong First Medical University, Jinan, Shandong

25 Department of Otolaryngology, The Fourth Hospital of Harbin Medical University, Nangang, Harbin, Heilongjiang

26 Department of Oncology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai

27 State Key Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

28 Department of Oncology, The Fourth Hospital of Harbin Medical University, Harbin, Heilongjiang

29 Department of Oncology, Cancer Prevention and Treatment Institute of Chengdu, Chengdu Fifth People’s Hospital (The Second Clinical Medical College Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, Sichuan

30 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, 200433

31 Department of Pathology, Sir Run Run Shaw Hospital of Zhejiang University College of Medicine & Sir Run Run Shaw Institute of Clinical Medicine of Zhejiang University, Hangzhou, Zhejiang

32 Department of Oncology, The First Hospital of Shanxi Medical University, Yingze, Taiyuan, Shanxi

33 Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, Genetic Diagnosis Center, the First Hospital of Jilin University, Changchun, Jilin

34 Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu

35 Department of Nuclear Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas

36 USC Michelson Center Convergent Science Institute in Cancer, Los Angeles, California

37 Department of Zoology, University of Benha, Benha

38 Departments of Urology and Pathology and the Biointerfaces Institute, University of Michigan, Ann Arbor, Michigan

39 Department of Pathology, College of Clinical Medicine for Oncology, Fujian Medical University, Fuzhou, Fujian

40 Department of Molecular Pathology, Clinical Pathology Center, Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan

41 Henan International Joint Laboratory of Children’s Infectious Diseases, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, Henan

42 Departments of Oncology & Immunotherapy, Hebei General Hospital, Shijiazhuang, Hebei

43 Department of Pathology, National Cancer Center, National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

44 Department of Clinical Pharmacology, Zhongshan Hospital, Fudan University, Shanghai

45 Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang

46 Department of Medical Oncology, Chongqing University Cancer Hospital, Shapingba, Chongqing

47 Department of Pathology, Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Shapingba, Chongqing

48 Division of Genome Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Box 1031, 171 21, Stockholm

49 Department of Trauma and Emergency Surgeon, The Second Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang

50 Department of Medical Oncology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang

51 Herbert Irving Comprehensive Cancer Center, Columbia University, New York City, New York

52 Department of Rare Tumors, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, Shandong

53 Department of Pathology, São João Local Health Unit, Faculty of Medicine, Institute for Research and Innovation in Health, Institute of Molecular Pathology and Immunology of University of Porto

54 Zhejiang Key Laboratory of Diagnosis & Treatment Technology on Thoracic Oncology (Lung and Esophagus), Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer, Department of Thoracic Medical Oncology, Zhejiang Cancer Hospital, Institute of Basic Medicine and Cancer, Chinese Academy of Sciences, Hangzhou, Zhejiang

55 Department of Neurosurgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing

56 Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

57 Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, Hunan

58 Institute of Biomedicine of Seville (Instituto de Biomedicina de Sevilla), Spanish National Research Council (Consejo Superior de Investigaciones Científicas), Seville

59 Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens

60 Department of Oncology, the third Xiangya Hospital, Central South University, Changsha, Hunan

61 Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, Hubei

62 Department of Pathology, Medical University of Graz, Graz, Styria

63 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai

64 Department of Oncology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang

65 Department of Molecular Microbiology & Immunology, Keck School of Medicine, University of Southern California (USC), Los Angeles, CA 90089

66 Surgical Science Training Center, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng 308433

67 Department of Pathology, Fujian Cancer Hospital Affiliated to Fujian Medical University, Fuzhou, Fujian

68 Blokhin National Medical Research Center of Oncology, Ministry of Health, Moscow

69 Molecular Cancer Genetics and Translational Research Lab, Section of Genetics, Aligarh Muslim University, Aligarh, Uttar Pradesh

70 Department of Oncology, Tangdu Hospital, Air Force Medical University, Xi’an, Shaanxi

71 Department of Oncology, Chongqing General Hospital, Chongqing University, Shapingba, Chongqing

72 Department of Internal Medicine, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan

73 Department of Medical Oncology, Peking University Shenzhen Hospital, Beijing University, Shenzhen, Guangdong

74 Department of Molecular Pathology, Henan Key Laboratory of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Henan

75 National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing

76 Department of Gastrointestinal Surgery, Affiliated Tumor Hospital of Nantong University, Nantong Tumor Hospital, Nantong, Jiangsu

77 Endoscopy Center of the Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou

78 epartment of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang

79 Department of Pulmonary Gastroenterology, Hunan Cancer Hospital, Changsha, Hunan

80 Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, Guangdong Institute of Gastroenterology; Department of Clinical Laboratory, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong

81 Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Hubei Key Laboratory of Tumor Biological Behaviors Hubei Cancer Clinical Study Center, Wuhan, Hubei

82 Department of Oncology, Southwest Hospital, Third Military Medical University (Army Medical University), Shapingba, Chongqing

83 Department of General Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan

84 Department of Oncology, Xijing Hospital, Air Force Medical University, Xincheng, Xi’an, Shaanxi

85 Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang

86 Research Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong

87 Department of Oncology, Shaanxi Cancer Hospital, Xi’an, Shaanxi

88 Breast Disease Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong

89 State Key Laboratory of Respiratory Diseases, National Clinical Research Center for Respiratory Diseases, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong

90 Department of Oncology, People’s Hospital of Shapingba, Shapingba, Chongqing

91 Department of Oncology, Xiangya Hospital, Central South University, No. 87, Changsha, Hunan

92 Guangdong-Hong Kong-Macau Great Bay Area Geroscience Joint Laboratory, School of Medicine, Jinan University, Guangzhou

93 Department of Pathology, Yale Center for Immuno-Oncology, Yale Cancer Center, Yale University, New Haven, Connecticut



Tumor Discovery 2024, 3(4),4904; https://doi.org/10.36922/td.4904
Submitted22 Sept 2024
Revised01 Jan 0001
Accepted14 Nov 2024
Published24 Dec 2024
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Xin Li ,Fei Xie ,Chao Deng ,Dan Yang ,Hongle Li ,Yuanzhi Lu ,Zhenbin Mao ,Qingwei Meng ,Lidong Wang ,Zhe Wang ,Jinliang Xing ,Chong Bai ,Zhimin Bian ,Paolo Boffano ,Steven Brower ,Rui Chen ,Wantao Chen ,Jinhai Deng ,Xinpei Deng ,Chunming Ding ,Jianchun Duan ,Song Duan ,Nejat Duzgunes ,Pierfrancesco Franco ,Guobin Fu ,Longmei Guo ,Ye Guo ,Ruiqin Han ,Ling Hao ,Lang He ,Yayi He ,Xiaotong Hu ,Junmei Jia ,Yanfang Jiang ,Weilin Jin ,Kalevi Kairemo ,Mohamed Kamal ,Evan T. Keller ,Rensheng Lai ,Chao Li ,Jun Li ,Lifeng Li ,Qingxia Li ,Wenbin Li ,Xuening Li ,Yang Li ,Yongsheng Li ,Yu Li ,Mikael S. Lindström ,Xiaodong Liu ,Yan Liu ,Yanqing Liu ,Zengjun Liu ,Jose Manuel Lopes ,Hongyang Lu ,Xiangwen Luo ,Wenping Ma ,Hongxue Meng ,Anjie Min ,Amancio Carnero Moya ,Athanasios G. Papavassiliou ,Xi Pan ,Min Peng ,Helmut H. Popper ,Lixin Qiu ,Di Qu ,Axel H. Schönthal ,Vishal Shelat ,Yi Shi ,Alexander Shtil ,Hifzur R Siddique ,Yang Song ,Haichuan Su ,Min Tang ,Mengyuan Wang ,Qiming Wang ,Shubin Wang ,Bing Wei ,Dawei Wu ,Longxiang Wu ,Liangbi Xu ,Yubo Yan ,Nong Yang ,Zihuan Yang ,Zongbi Yi ,Songtao Yu ,Heng Zhang ,Hongmei Zhang ,Lijuan Zhang ,Jianfu Zhao ,Zheng Zhao ,Shaoquan Zheng ,Chengzhi Zhou ,Pu Zhou ,Qin Zhou ,Guodong Zhu ,Qin Yan ,Minghui Zhang ,Mingzhu Yin . (2024). <p>Expert consensus and current landscape of NUT carcinoma: A comprehensive strategy from diagnosis to treatment</p>. Tumor Discovery , 3(4), td4904. https://doi.org/10.36922/td.4904
Abstract

Nuclear protein of the testis (NUT) carcinoma is a rare and highly aggressive malignancy characterized by the rearrangement of the NUT midline carcinoma family member 1 (NUTM1) gene. Nevertheless, standardized strategies for its diagnosis and treatment remain unavailable, underscoring the need for expert consensus. To address this gap, we conducted a systematic review to gather comprehensive information on NUT carcinoma from five databases: PubMed, Web of Science, Embase, Cochrane Library, and Ovid Medline. This expert consensus was collaboratively developed by a team of international multidisciplinary experts, in partnership with the NUT Carcinoma Diagnosis Working Group of the Chinese Anti-Cancer Association’s Oncogene Diagnosis Professional Committee. This working group comprises medical oncologists, radiation oncologists, surgical oncologists, pathologists, nurses, molecular biologists, statisticians, and bioinformatics specialists. A systematic review, based on data from 526 patients across 199 articles, was conducted to comprehensively explore various characteristics, including demographic features (e.g., patient gender, distribution regions, and age), tumor-node-metastasis (TNM) classification stage, clinical symptoms, tumor size, metastatic patterns, immunohistochemical (IHC) findings, treatment modalities, prognosis-related information, and NUTM1 fusion partners. We have developed an expert consensus on diagnosing and treating NUT carcinoma using a multidisciplinary approach. The guideline provides eight recommendations, addressing epidemiological characteristics, clinical and imaging manifestations, pathological findings, IHC features, molecular mechanisms and subtypes, prognosis, diagnosis, and treatment strategies for NUT carcinoma. Furthermore, an international platform has been established to disseminate NUT carcinoma knowledge and patient recruitment, providing patients and healthcare providers access to NUT carcinoma-related information and updates on clinical trial recruitment.

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