Atropine-induced psychosis, though rare, is a critical adverse effect that can arise during the treatment of organophosphate (OP) poisoning, necessitating swift recognition for optimal patient care. This case report describes the presentation of a 45-year-old male with a history of chronic alcoholism and smoking, admitted for OP intoxication, who developed acute psychosis after atropine administration. The symptoms included hallucinations, agitation, and delirium, with diagnostic evaluation confirming atropine-induced psychosis according to DSM-IV-TR criteria. The treatment approach involved discontinuing atropine and providing supportive care, which resulted in symptom resolution within several days. In addition, benzodiazepines were administered to manage agitation and anxiety. This case highlights the need for careful monitoring of drug reactions, particularly in patients with risk factors, such as chronic alcoholism. It underscores the importance of individualized treatment strategies and the critical role of healthcare professionals in recognizing and addressing atropine-induced psychosis. Further research is warranted to better understand the underlying mechanisms and risk factors associated with this complication.

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